Journal article
Edoxaban versus Warfarin in Patients with Atrial Fibrillation
Abstract
BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known.
METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The …
Authors
Giugliano RP; Ruff CT; Braunwald E; Murphy SA; Wiviott SD; Halperin JL; Waldo AL; Ezekowitz MD; Weitz JI; Špinar J
Journal
New England Journal of Medicine, Vol. 369, No. 22, pp. 2093–2104
Publisher
Massachusetts Medical Society
Publication Date
November 28, 2013
DOI
10.1056/nejmoa1310907
ISSN
0028-4793