Journal article
Impact of non-binder ingredients and molecular weight of polymer binders on heat assisted twin screw dry granulation
Abstract
Two grades of commercial AFFINISOL™ HPMC HME were used as polymer binders to explore the influence of polymer viscosity and concentration on a novel heat assisted dry granulation process with a twin screw extruder. Contributions of other non-binder ingredients in the formulations were also studied for lactose, microcrystalline cellulose and an active pharmaceutical ingredient of caffeine. As sensitive indicators of processing conditions that …
Authors
Liu Y; Thompson MR; O’Donnell KP
Journal
International Journal of Pharmaceutics, Vol. 536, No. 1, pp. 336–344
Publisher
Elsevier
Publication Date
January 2018
DOI
10.1016/j.ijpharm.2017.11.061
ISSN
0378-5173