Conference
Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease
Abstract
Abstract
Notch signaling is a critical regulator of T cell effector functions during acute graft-versus-host disease (GVHD). Pan-Notch inhibition in donor-derived T cells or systemic antibody-mediated blockade of Delta-like1 (Dll1) and Delta-like4 (Dll4) Notch ligands results in near-complete protection from acute GVHD in mouse models of allogeneic bone marrow transplantation. Notch-deprived alloreactive T cells proliferate …
Authors
Chung J; Ebens CL; Radojcic V; Koch U; Friedman A; Tran IT; Chai Q; Onder L; Yan M; Reddy P
Volume
124
Publisher
American Society of Hematology
Publication Date
December 6, 2014
DOI
10.1182/blood.v124.21.841.841
Conference proceedings
Blood
Issue
21
ISSN
0006-4971