Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate Journal Articles uri icon

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  • SummaryObjectiveEpileptic spasms (ES) often become drug‐resistant. To reveal the electrophysiological difference between children with ES (ES+) and without ES (ES−), we compared the occurrence rate (OR) of high‐frequency oscillations (HFOs) and the modulation index (MI) of coupling between slow and fast oscillations.In ES+, we hypothesized that (1) pathological HFOs are more widely distributed and (2) slow oscillations show stronger coupling with pathological HFOs than in ES−.MethodsWe retrospectively reviewed 24 children with drug‐resistant multilobar onset epilepsy, who underwent intracranial video electroencephalography prior to multilobar resections. We measured the OR of HFOs and determined the electrodes with a high rate of HFOs by cluster analysis. We calculated MI, which reflects the degree of coupling between HFO (ripple/fast ripple [FR]) amplitude and 5 different frequency bands of delta and theta activities (0.5‐1 Hz, 1‐2 Hz, 2‐3 Hz, 3‐4 Hz, 4‐8 Hz).ResultsIn ES+ (n = 10), the OR(FRs), the number of electrodes with high‐rate FRs, and the MI(FRs & 3‐4 Hz) in all electrodes were significantly higher than in ES− (n = 14). In both the ES+ and ES− groups, MI(ripples/FRs & 3‐4 Hz) was the highest among the 5 frequency bands. Within the good seizure outcome group, the OR(FRs) and the MI(FRs & 3‐4 Hz) in the resected area in ES+ were significantly higher than in ES− (OR[FRs], P = .04; MI[FRs & 3‐4 Hz], P = .04).SignificanceIn ES+, the larger number of high‐rate FR electrodes indicates more widespread epileptogenicity than in ES−. High values of OR(FRs) and MI(FRs & 3‐4 Hz) in ES+ compared to ES− are a signature of the severity of epileptogenicity. We proved that ES+ children who achieved seizure freedom following multilobar resections exhibited strong coupling between slow oscillations and FRs.


  • Iimura, Yasushi
  • Jones, Kevin Charles
  • Takada, Lynne
  • Shimizu, Itsuki
  • Koyama, Misaki
  • Hattori, Kyoko
  • Okazawa, Yushi
  • Nonoda, Yutaka
  • Asano, Eishi
  • Akiyama, Tomoyuki
  • Go, Cristina
  • Ochi, Ayako
  • Snead, O Carter
  • Donner, Elizabeth J
  • Rutka, James T
  • Drake, James M
  • Otsubo, Hiroshi

publication date

  • March 2018