Journal article
Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial
Abstract
Importance: Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor.
Objective: To investigate whether TTFields improves progression-free and overall survival of patients with glioblastoma, a fatal disease that commonly recurs at the initial tumor site or in the central nervous system.
Authors
Stupp R; Taillibert S; Kanner A; Read W; Steinberg DM; Lhermitte B; Toms S; Idbaih A; Ahluwalia MS; Fink K
Journal
JAMA: The Journal of the American Medical Association, Vol. 318, No. 23, pp. 2306–2316
Publisher
American Medical Association (AMA)
Publication Date
December 19, 2017
DOI
10.1001/jama.2017.18718
ISSN
0098-7484