Journal article
The expression of matrix metalloproteinases and their inhibitors by pig synovial cells and their regulation by combinations of cytokines and growth factors
Abstract
1. Pig synovial fibroblasts in culture were studied to determine if they were an easily reproducible model system for studying the actions of cytokines and growth factors on human synovial cells. The biochemical analyses were conducted by activity assays, enzymography and Northern blot. 2. Human recombinant interleukin-1 alpha, basic fibroblast growth factor and transforming growth factor-beta 1 were studied in combinations because of their …
Authors
Legendre P; Richards CD; Rafferty JA; Dew GW; Reynolds JJ
Journal
Comparative Biochemistry and Physiology Part B Comparative Biochemistry, Vol. 106, No. 3, pp. 691–704
Publisher
Elsevier
Publication Date
November 1993
DOI
10.1016/0305-0491(93)90151-t
ISSN
0305-0491