Journal article
Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder
Abstract
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been proposed as a possible candidate for involvement in the pathophysiology of bipolar disorder (BD). To determine whether an association exists between the BDNF Val66Met genotype and morphometric abnormalities of the brain regions involved in memory and learning in BD and healthy subjects. Forty-two BD patients and 42 healthy subjects were studied. Interactions between …
Authors
Matsuo K; Walss-Bass C; Nery FG; Nicoletti MA; Hatch JP; Frey BN; Monkul ES; Zunta-Soares GB; Bowden CL; Escamilla MA
Journal
Neuropsychopharmacology, Vol. 34, No. 8, pp. 1904–1913
Publisher
Springer Nature
Publication Date
July 2009
DOI
10.1038/npp.2009.23
ISSN
0893-133X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAmino Acid SubstitutionBipolar DisorderBrainBrain-Derived Neurotrophic FactorDNA Mutational AnalysisFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic TestingGenotypeGyrus CinguliHippocampusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMutationNeuropsychological TestsPolymorphism, GeneticPrefrontal Cortex