Journal article
Exercise-induced Refractoriness in Asthmatic Subjects Involves Leukotriene and Prostaglandin Interdependent Mechanisms
Abstract
Exercise-induced bronchoconstriction is caused, in part, by leukotriene (LT)D4 release in asthmatic airways. Asthmatics become refractory to exercise bronchoconstriction with repeated challenges, due to inhibitory prostaglandin release. The purpose of this study was to test the hypothesis that exercise refractoriness is caused by LTD4-induced inhibitory prostaglandin release. Fourteen stable asthmatic subjects with exercise-induced …
Authors
Manning PJ; Watson RM; O'Byrne PM
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 148, No. 4_pt_1, pp. 950–954
Publisher
American Thoracic Society
Publication Date
October 1993
DOI
10.1164/ajrccm/148.4_pt_1.950
ISSN
1073-449X