Elevated 3,4-dihydroxyphenylethyleneglycol (DHPG) excretion in dexamethasone resistant depressed patients Academic Article uri icon

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  • Urinary and plasma DHPG and MHPG were estimated in patients with MADD and showing DST non-suppression as compared to those with normal suppression. Day and night 12h urine collections and morning plasma samples were analyzed by GC-MS for total MHPG and DHPG and free MHPG levels. Urinary DHPG excretion was significantly elevated in DST non-suppressors compared to suppressors, but no differences were found in urinary MHPG or plasma glycol levels. Elevated DHPG excretion in DST non-suppressors suggests that increased peripheral sympathetic NE activity occurs in association with dexamethasone resistance in MADD.


  • Warsh, Jerry J
  • Hasey, Gary Marcel
  • Cooke, Robert G
  • Stancer, Harvey C
  • Persad, Emmanuel
  • Jorna, Thecla
  • Godse, Damodar D

publication date

  • January 1985