Only Two Weeks of Physical Inactivity Induces Insulin Resistance and Impairs Glycemic Control in Older Adults

Periods of physical inactivity are known to result in deleterious consequences for skeletal muscle mass, strength, and insulin sensitivity. We propose that even transient periods of reduced activity likely have a greater impact in older individuals who often fail to fully recover. We aimed to examine the impact of two weeks of step reduction (SR), as a model of physical inactivity akin to that occurring during illness, on indices of glycemic …