Journal article
Skeletal Muscle Metabolic Dysfunction in Patients With Malignant Hyperthermia Susceptibility
Abstract
BACKGROUND: Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise intolerance in patients tested positive for MH …
Authors
Thompson SJ; Riazi S; Kraeva N; Noseworthy MD; Rayner TE; Schneiderman JE; Cifra B; Wells GD
Journal
Anesthesia & Analgesia, Vol. 125, No. 2, pp. 434–441
Publisher
Wolters Kluwer
Publication Date
August 2017
DOI
10.1213/ane.0000000000002232
ISSN
0003-2999