Tuberculosis/cryptococcosis co-infection in China between 1965 and 2016 Journal Articles uri icon

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  • Cases of tuberculosis/cryptococcosis co-infection are rapidly increasing in China. However, most studies addressing this co-infection have been published in Chinese journals, and this publication strategy has obscured this disease trend for scientists in other parts of the world. Our investigation found that 62.9% of all co-infection cases worldwide were reported in the Chinese population (n=197) between 1965 and 2016, and 56.3% of these Chinese cases were reported after 2010. Nearly all cases originated from the warm and wet monsoon regions of China. HIV-positive subjects tended to correlate with more severe manifestations of a tuberculosis/cryptococcosis co-infection than those without HIV. Notablely, dual tubercular/cryptococcal meningitis was the most frequent (54.0%) and most easily misdiagnosed (95.2%, n=40/42) co-infection. We also found that the combined use of cerebrospinal fluid pressure and concentrations of glucose, protein and chlorine might be an inexpensive and effective indicator to differentiate tubercular/cryptococcal co-infection meningitis from tubercular meningitis and cryptococcal meningitis.


  • Fang, Wenjie
  • Zhang, Lei
  • Liu, Jia
  • Denning, David W
  • Hagen, Ferry
  • Jiang, Weiwei
  • Hong, Nan
  • Deng, Shuwen
  • Lei, Xia
  • Deng, Danqi
  • Liao, Wanqing
  • Xu, Jianping
  • Boekhout, Teun
  • Chen, Min
  • Pan, Weihua

publication date

  • January 2017