Detection of Hemorrhagic Hypointense Foci in the Brain on Susceptibility-Weighted Imaging Academic Article uri icon

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  • RATIONALE AND OBJECTIVES: To determine the sensitivity of susceptibility-weighted imaging (SWI) for depicting hemorrhagic hypointense foci of the brain in comparison with gradient-recalled echo (GRE)- and GRE-type single-shot echo-planar imaging (GREI, GRE-EPI), and to assess the basic characteristics of the susceptibility effect by using a phantom. MATERIALS AND METHODS: We prospectively examined 16 patients (9 males, 7 females, aged 10-74 years, mean 43 years) with hypointense foci using SWI, GREI, and GRE-EPI at a 1.5-T magnetic resonance (MR) unit. The contrast-to-noise ratio (CNR), sensitivity to small hypointese foci, and artifacts were evaluated. To assess the basic characteristics of SWI, we performed a phantom study using different concentrations of superparamagnetic iron oxide (SPIO). RESULTS: The CNR of lesions was significantly greater for SWI than the other images (P < .0001). SWI detected the greatest number of small hypointense foci, even in the near-skull-base and infratentorial regions. Quantitative and qualitative analyses in our clinical and phantom studies demonstrated that the degree of artifacts was similar with SWI and GREI. CONCLUSION: SWI was best for detecting small hemorrhagic hypointense foci. Artifacts of SWI were similar to GREI.


  • Akter, Masuma
  • Hirai, Toshinori
  • Hiai, Yasuhiro
  • Kitajima, Mika
  • Komi, Masanori
  • Murakami, Ryuji
  • Fukuoka, Hirofumi
  • Sasao, Akira
  • Toya, Ryo
  • Haacke, Mark
  • Takahashi, Mutsumasa
  • Hirano, Teruyuki
  • Kai, Yutaka
  • Morioka, Motohiro
  • Hamasaki, Kiyotoshi
  • Kuratsu, Jun-ichi
  • Yamashita, Yasuyuki

publication date

  • September 2007