Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children Academic Article uri icon

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abstract

  • OBJECTIVE: To find the best lead exposure assessment marker for children. METHODS: We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level. RESULTS: Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score. CONCLUSION: Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.

authors

  • Nie, Linda H
  • Wright, Robert O
  • Bellinger, David C
  • Hussain, Javed
  • Amarasiriwardena, Chitra
  • Chettle, David
  • Pejović-Milić, Ana
  • woolf, Alan
  • Shannon, Michael

publication date

  • September 2011