The disadvantages of conventional metalworking fluids such as disposal problems, health problems and economic factors have led to the development of strategies to reduce their amount in metalworking. Recently, Minimum Quantity Lubrication (MQL) technology was developed and it seems to be a suitable alternative for economically and environmentally compatible production. It combines the functionality of lubrication with an extremely low consumption of lubricant and has a potential to replace metalworking fluids application in machining operations. The MQL lubricants are formulated with two major groups of additives; anti-wear (AW) additives and extreme pressure (EP) additives. When such lubricants are applied to the cutting zone, protective layers are formed on the interacting surfaces of the workpiece and the cutting tool. These layers prevent direct contact between the tool and chip surfaces, and, therefore reduce friction forces and tool wear. In order to utilize MQL to its full potential, it is essential to select appropriate lubricant composition for particular work material and machining parameters. The experimental study of different compositions of MQL lubricants is reported. The effectiveness of the lubricants are determined in terms of their ability to protect the cutting tool in high speed machining of cast aluminum alloys, which are widely used in automotive industry. The main objective of this research is to quantitatively evaluate the ability of lubricant’s additive composition to reduce the tool wear. This is reached through the comparison between the tool wear rate measured during the machining of aluminum cast alloy with the application of MQL, and the tool wear rate obtained in dry machining of the same alloy. Two kinds of the lubricants are evaluated; vegetable and synthetic. The content of AW and EP additives in each kind of lubricant was varied on three levels in order to capture the effect of the lubricant’s composition on tool wear. The result of the MQL lubricants evaluation is discussed and the recommendations for optimal lubricant composition are made.