Journal article
Pulmonary neuroepithelial bodies are polymodal airway sensors: Evidence for CO2/H+ sensing
Abstract
Pulmonary neuroepithelial bodies (NEB) in mammalian lungs are thought to function as airway O2 sensors that release serotonin (5-HT) in response to hypoxia. Direct evidence that NEB cells also respond to airway hypercapnia/acidosis (CO2/H(+)) is presently lacking. We tested the effects of CO2/H(+) alone or in combination with hypoxia on 5-HT release from intact NEB cells in a neonatal hamster lung slice model. For the detection of 5-HT release …
Authors
Livermore S; Zhou Y; Pan J; Yeger H; Nurse CA; Cutz E
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 308, No. 8, pp. l807–l815
Publisher
American Physiological Society
Publication Date
April 15, 2015
DOI
10.1152/ajplung.00208.2014
ISSN
1040-0605