Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection Academic Article uri icon

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abstract

  • We demonstrate a silicon photonic wire waveguide biosensor array chip for the simultaneous monitoring of different molecular binding reactions. The chip is compatible with automated commercial spotting tools and contains a monolithically integrated microfluidic channel for sample delivery. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 microm diameter spot and is incorporated in a balanced Mach-Zehnder interferometer with a near temperature independent response. The sensors are arranged in a 400 microm spacing grid pattern and are addressed through cascaded 1x2 optical power splitters using light from a single input fiber. We demonstrate the real-time monitoring of antibody-antigen reactions using complementary and mismatched immunoglobulin G receptor-analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than 0.3 pg/mm(2).

authors

  • Densmore, A
  • Vachon, M
  • Xu, D-X
  • Janz, S
  • Ma, R
  • Li, Y-H
  • Lopinski, G
  • Delâge, A
  • Lapointe, J
  • Luebbert, CC
  • Liu, QY
  • Cheben, Pavel
  • Schmid, JH

publication date

  • December 1, 2009