Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach Academic Article uri icon

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abstract

  • We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg/mm(2) (40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM. Reactions are measured over time periods as long as 3 h with high stability.

authors

  • Xu, D-X
  • Vachon, M
  • Densmore, A
  • Ma, R
  • Delâge, A
  • Janz, S
  • Lapointe, J
  • Li, Y
  • Lopinski, G
  • Zhang, D
  • Liu, QY
  • Cheben, Pavel
  • Schmid, JH

publication date

  • August 15, 2010