Advances in Understanding Inflammation in Esophageal Disease

Gastroesophageal reflux disease (GERD) is a common chronic disorder that causes reflux symptoms and/or muscosal damage, associated with Barrett’s esophagus and esophageal adenocarcinoma, and greatly impacts on the quality of life. Gastric acid plays a critical role in the pathogenesis especially in regard to inflammation of the esophageal mucosa and initiating symptoms; the more the acid reflux, the more severe the disease. It is known that …