Circulating Nucleic Acids of
Chlamydia pneumoniae
and Cytomegalovirus in Patients Undergoing Coronary Angiography
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ABSTRACT
Peripheral blood mononuclear cells from 208 consecutive patients undergoing elective coronary angiography or angioplasty were collected before, immediately after, and 4 h after the procedure. Nucleic acids of
Chlamydia pneumoniae
and of cytomegalovirus (CMV) were detected by PCR and confirmed by hybridization. Circulating
C. pneumoniae
DNA was identified in 24 patients (11.5%) and was associated with current smoking (odds ratio [OR] = 4.5, 95% confidence interval [CI] = 1.6 to 12.2,
P
= 0.004) but not with arterial narrowing on coronary angiogram or with serological results positive for
C. pneumoniae
. Circulating CMV DNA was identified in 36 patients (17.3%) and was associated with anti-CMV immunoglobulin G (OR = 2.7, 95% CI = 1.2 to 6.3,
P
= 0.02) but not with angiographic arterial narrowing or with the need for revascularization. Neither
C. pneumoniae
nor CMV DNA detection increased after angioplasty, a procedure in which endothelium is disrupted. Larger prospective studies are needed to determine the prognostic significance of DNA detection.
