keywords BARRETTS-ESOPHAGUS DOUBLE-BLIND ESOPHAGEAL ACID EXPOSURE GASTRIN-RECEPTOR ANTAGONIST GASTROESOPHAGEAL-REFLUX DISEASE GUARANTEE NORMALIZATION Gastroenterology & Hepatology INTRAGASTRIC PH Life Sciences & Biomedicine NIGHTTIME HEARTBURN P-CABs PLASMA HALF-LIFE PROTON-PUMP INHIBITORS Science & Technology esophagitis nocturnal acid proton pump inhibitor