Journal article
Injectable Microgel-Hydrogel Composites for Prolonged Small-Molecule Drug Delivery
Abstract
The design and application of soft nanocomposite injectable hydrogels containing entrapped microgels for small-molecule drug delivery is demonstrated. Copolymer microgels based on N-isopropylacrylamide and acrylic acid were synthesized that exhibited both ionic and hydrophobic affinity for binding to bupivacaine, a cationic local anesthetic used as a model drug. Microgels were subsequently immobilized within an in situ-gelling hydrogel network …
Authors
Sivakumaran D; Maitland D; Hoare T
Journal
Biomacromolecules, Vol. 12, No. 11, pp. 4112–4120
Publisher
American Chemical Society (ACS)
Publication Date
November 14, 2011
DOI
10.1021/bm201170h
ISSN
1525-7797