Journal article
In vivo detection of macrophages in a rabbit atherosclerotic model by time-resolved laser-induced fluorescence spectroscopy
Abstract
Accumulation of numerous macrophages in the fibrous cap is a key identifying feature of plaque inflammation and vulnerability. This study investigates the use of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) as a potential tool for detection of macrophage foam cells in the intima of atherosclerotic plaques. Experiments were conducted in vivo on 14 New Zealand rabbits (6 control, 8 hypercholesterolemic) following aortotomy to …
Authors
Marcu L; Fang Q; Jo JA; Papaioannou T; Dorafshar A; Reil T; Qiao J-H; Baker JD; Freischlag JA; Fishbein MC
Journal
Atherosclerosis, Vol. 181, No. 2, pp. 295–303
Publisher
Elsevier
Publication Date
8 2005
DOI
10.1016/j.atherosclerosis.2005.02.010
ISSN
0021-9150