Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies Academic Article uri icon

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  • Autoantibodies to nodal/paranodal proteins have been reported in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). To determine the frequency of anti-paranodal antibodies in our cohort of CIDP patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA. In CIDP patients, 7% were anti-NF155 IgG4 positive and 7% were anti-CNTN1 IgG4 positive. Positive results were confirmed using cell based assays and indirect immunofluorescence on teased nerve fibres. We did not detect IgG autoantibodies against these nodal/paranodal antigens in MMN patients.


  • Mathey, EK
  • Garg, N
  • Park, SB
  • Nguyen, T
  • Baker, Steven
  • Yuki, N
  • Yiannikas, C
  • Lin, CS
  • Spies, JM
  • Ghaoui, R
  • Barnett, MH
  • Vucic, S
  • Pollard, JD
  • Kiernan, MC

publication date

  • August 2017

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