Journal article
Novel biomarkers for risk of prostate cancer: Results from a case–control study
Abstract
BACKGROUND: Although the estrogens estrone and estradiol are recognized to play very important roles in the risk of developing prostate cancer (Pca), the molecular mechanism by which estrogens initiate and/or promote Pca is still unknown. Substantial evidence supports that specific metabolites of estrogens, catechol estrogen quinones, can react with DNA to form depurinating estrogen-DNA adducts. Apurinic sites derived from depurination of these …
Authors
Yang L; Gaikwad NW; Meza J; Cavalieri EL; Muti P; Trock B; Rogan EG
Journal
The Prostate, Vol. 69, No. 1, pp. 41–48
Publisher
Wiley
Publication Date
January 2009
DOI
10.1002/pros.20850
ISSN
0270-4137