Solar insolation in springtime influences age of onset of bipolar I disorder Academic Article uri icon

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abstract

  • OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

authors

  • Bauer, M
  • Glenn, T
  • Alda, M
  • Aleksandrovich, MA
  • Andreassen, OA
  • Angelopoulos, E
  • Ardau, R
  • Ayhan, Y
  • Baethge, C
  • Bharathram, SR
  • Bauer, R
  • Baune, BT
  • Becerra-Palars, C
  • Bellivier, F
  • Belmaker, RH
  • Berk, M
  • Bersudsky, Y
  • Bicakci, Ş
  • Birabwa-Oketcho, H
  • Bjella, TD
  • Bossini, L
  • Cabrera, J
  • Cheung, EYW
  • Del Zompo, M
  • Dodd, S
  • Donix, M
  • Etain, B
  • Fagiolini, A
  • Fountoulakis, KN
  • Frye, MA
  • Gonzalez-Pinto, A
  • Gottlieb, JF
  • Grof, P
  • Harima, H
  • Henry, C
  • Isometsä, ET
  • Janno, S
  • Kapczinski, Flavio
  • Kardell, M
  • Khaldi, S
  • Kliwicki, S
  • König, B
  • Kot, TL
  • Krogh, R
  • Kunz, M
  • Lafer, B
  • Landén, M
  • Larsen, ER
  • Lewitzka, U
  • Licht, RW
  • Lopez-Jaramillo, C
  • MacQueen, Glenda
  • Manchia, M
  • Marsh, W
  • Martinez-Cengotitabengoa, M
  • Melle, I
  • Meza-Urzúa, F
  • Yee Ming, M
  • Monteith, S
  • Morken, G
  • Mosca, E
  • Munoz, R
  • Mythri, SV
  • Nacef, F
  • Nadella, RK
  • Nery, FG
  • Nielsen, RE
  • O'Donovan, C
  • Omrani, A
  • Osher, Y
  • Østermark Sørensen, H
  • Ouali, U
  • Pica Ruiz, Y
  • Pilhatsch, M
  • Pinna, M
  • da Ponte, FDR
  • Quiroz, D
  • Ramesar, R
  • Rasgon, N
  • Reddy, MS
  • Reif, A
  • Ritter, P
  • Rybakowski, JK
  • Sagduyu, K
  • Scippa, ÂM
  • Severus, E
  • Simhandl, C
  • Stein, DJ
  • Strejilevich, S
  • Subramaniam, M
  • Sulaiman, AH
  • Suominen, K
  • Tagata, H
  • Tatebayashi, Y
  • Tondo, L
  • Torrent, C
  • Vaaler, AE
  • Veeh, J
  • Vieta, E
  • Viswanath, B
  • Yoldi-Negrete, M
  • Zetin, M
  • Zgueb, Y
  • Whybrow, PC

publication date

  • December 2017