selected scholarly activity
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academic article
- Thermal-hydraulics analysis of flow blockage events for fuel assembly in a sodium-cooled fast reactor. International Journal of Heat and Mass Transfer. 138:496-507. 2019
- Antibody-mediated targeting of cleavage-specific OPN-T cell interactions. PLoS ONE. 14:e0214938-e0214938. 2019
- Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients. Arthritis Research and Therapy Arthritis Research. 20:132. 2018
- A review on recent heat transfer studies to supercritical pressure water in channels. Applied Thermal Engineering. 142:573-596. 2018
- Decoding the Genomics of Abdominal Aortic Aneurysm. Cell. 174:1361-1372.e10. 2018
- Carboxypeptidase B2 and carboxypeptidase N in the crosstalk between coagulation, thrombosis, inflammation, and innate immunity. Journal of Thrombosis and Haemostasis. 16:1474-1486. 2018
- Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice. Journal of Thrombosis and Haemostasis. 16:991-1002. 2018
- Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma. American Journal of Sports Medicine. 46:409-419. 2018
- Prochemerin cleavage by factor XIa links coagulation and inflammation. Blood. 131:353-364. 2018
- Dynamic and tissue-specific proteolytic processing of chemerin in obese mice. PLoS ONE. 13:e0202780-e0202780. 2018
- A predictive-corrective process for predicting forced convective heat transfer in heated tubes at supercritical pressures. International Journal of Heat and Mass Transfer. 110:374-382. 2017
- Improvement of buoyancy and acceleration parameters for forced and mixed convective heat transfer to supercritical fluids flowing in vertical tubes. International Journal of Heat and Mass Transfer. 106:1144-1156. 2017
- Chemerin activation in human obesity. Obesity Research Obesity. 24:1522-1529. 2016
- Heat transfer from a 2 × 2 wire-wrapped rod bundle to supercritical pressure water. International Journal of Heat and Mass Transfer. 97:486-501. 2016
- Experiments on the basic behavior of supercritical CO 2 natural circulation. Nuclear Engineering and Design. 300:376-383. 2016
- Plasmin as a complement C5 convertase. EBioMedicine. 5:20-21. 2016
- Assessment of Computational Tools in Support of Heat-Transfer Correlation Development for Fuel Assembly of Canadian Supercritical Water-Cooled Reactor. Journal of Nuclear Engineering and Radiation Science. 2. 2016
- Heat transfer effectiveness for cooling of Canadian SCWR fuel assembly under the LOCA/LOECC scenario. Annals of Nuclear Energy. 81:306-319. 2015
- Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model. Journal of Thrombosis and Haemostasis. 13:1090-1102. 2015
- Overview of methods to increase dryout power in CANDU fuel bundles. Nuclear Engineering and Design. 287:131-138. 2015
- Review of R&D for supercritical water cooled reactors. Progress in Nuclear Energy. 77:282-299. 2014
- Thrombin Cleavage of Osteopontin Disrupts a Pro-chemotactic Sequence for Dendritic Cells, Which Is Compensated by the Release of Its Pro-chemotactic C-terminal Fragment. Journal of Biological Chemistry. 289:27146-27158. 2014
- Experimental investigation of heat transfer from a 2×2 rod bundle to supercritical pressure water. Nuclear Engineering and Design. 275:205-218. 2014
- Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis. Arthritis and Rheumatology. 66:101-106. 2014
- Assessment of CHF characteristics at subcooled conditions for the CANFLEX bundle. Nuclear Engineering and Design. 264:119-125. 2013
- Issues and future direction of thermal-hydraulics research and development in nuclear power reactors. Nuclear Engineering and Design. 264:3-23. 2013
- Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding. Transfusion. 54:n/a-n/a. 2013
- Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proceedings of the National Academy of Sciences of the United States of America. 110:6061-6066. 2013
- Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage. Journal of Biological Chemistry. 288:3097-3111. 2013
- Differential Gene Expression in Thrombomodulin (TM; CD141)+ and TM− Dendritic Cell Subsets. PLoS ONE. 8:e72392-e72392. 2013
- Microfluidic impedance cytometer for platelet analysis. Lab on a Chip - Miniaturisation for Chemistry and Biology. 13:722-722. 2013
- Chemerin158K Protein Is the Dominant Chemerin Isoform in Synovial and Cerebrospinal Fluids but Not in Plasma. Journal of Biological Chemistry. 286:39520-39527. 2011
- Proteolytic Cleavage of Chemerin Protein Is Necessary for Activation to the Active Form, Chem157S, Which Functions as a Signaling Molecule in Glioblastoma. Journal of Biological Chemistry. 286:39510-39519. 2011
- Experimental investigation of heat transfer for supercritical pressure water flowing in vertical annular channels. Nuclear Engineering and Design. 241:4045-4054. 2011
- Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. Journal of Clinical Investigation. 121:3517-3527. 2011
- Enhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B–Deficient Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1363-1370. 2010
- Polyphosphate binds with high affinity to exosite II of thrombin. Journal of Thrombosis and Haemostasis. 8:548-555. 2010
- Heparin-induced thrombosis without thrombocytopenia. Journal of Thoracic and Cardiovascular Surgery. 139:e6-e7. 2010
- Coupled neutronics/thermal–hydraulics analysis of CANDU–SCWR fuel channel. Annals of Nuclear Energy. 37:58-65. 2010
- What has been learnt from the Thrombin Activatable Fibrinolysis Inhibitor (TAFI)-deficient mouse?. Journal of Thrombosis and Haemostasis. 8:868-876. 2010
- Proteolytic regulatory mechanism of chemerin bioactivity. Acta Biochimica et Biophysica Sinica Acta Biochimica et Biophysica Sinica. 41:973-979. 2009
- Subchannel analysis of CANDU-SCWR fuel. Progress in Nuclear Energy. 51:799-804. 2009
- SCWR subchannel code ATHAS development and CANDU-SCWR analysis. Nuclear Engineering and Design. 239:1979-1987. 2009
- Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. Arthritis and Rheumatism. 60:2902-2912. 2009
- PREDICTIONS OF CRITICAL HEAT FLUX USING THE ASSERT-PV SUBCHANNEL CODE FOR A CANFLEX VARIANT BUNDLE. Nuclear Engineering and Technology. 41:969-978. 2009
- Effect of CANDU Bundle-Geometry Variation on Dryout Power. Journal of Engineering for Gas Turbines and Power. 131. 2009
- Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets. Journal of Biological Chemistry. 284:751-758. 2009
- Thrombospondin type I domain containing 7A (THSD7A) mediates endothelial cell migration and tube formation. Journal of Cellular Physiology. 222:n/a-n/a. 2009
- Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Molecular Immunology. 45:4080-4083. 2008
- Thrombin Hydrolysis of Human Osteopontin Is Dependent on Thrombin Anion-binding Exosites. Journal of Biological Chemistry. 283:17789-17796. 2008
- Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina?. American Heart Journal. 154:1059-1064. 2007
- Erratum (Retracted article): Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ibα with thrombin anion-binding exosites I and II, respectively (Journal of Biological Chemistry (2003) 278 (48112-48119)). Journal of Biological Chemistry. 282:29067. 2007
- A Study of the Mechanics of Porous Plga 85/15 Scaffold in Compression. Polymers and Polymer Composites Engineering plastics. 15:437-443. 2007
- Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. Blood. 109:1992-1997. 2007
- Venous Thromboembolic Disease. Journal of the National Comprehensive Cancer Network : JNCCN. 4:838-838. 2006
- An experimental and analytical study of the effect of axial power profile on CHF. Nuclear Engineering and Design. 236:1384-1395. 2006
- Antiangiogenic Antithrombin Induces Global Changes in the Gene Expression Profile of Endothelial Cells. Cancer Research. 66:5047-5055. 2006
- Lookup Tables for Predicting CHF and Film-Boiling Heat Transfer: Past, Present, and Future. Nuclear Technology. 152:87-104. 2005
- Exosite-interactive Regions in the A1 and A2 Domains of Factor VIII Facilitate Thrombin-catalyzed Cleavage of Heavy Chain. Journal of Biological Chemistry. 280:18476-18487. 2005
- Prediction of the obstacle effect on film-boiling heat transfer. Nuclear Engineering and Design. 235:687-700. 2005
- Pressure drops for steam and water flow in heated tubes. Nuclear Engineering and Design. 235:53-65. 2005
- Molecular Mapping of the Thrombin-Heparin Cofactor II Complex. Journal of Biological Chemistry. 279:43237-43244. 2004
- Crystal Structure of Anticoagulant Thrombin Variant E217K Provides Insights into Thrombin Allostery. Journal of Biological Chemistry. 279:26387-26394. 2004
- Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells. Blood. 103:1185-1191. 2004
- Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms. Genomics. 83:24-33. 2004
- Thrombin Activatable Fibrinolysis Inhibitor, a Potential Regulator of Vascular Inflammation. Journal of Biological Chemistry. 278:51059-51067. 2003
- Thrombin Activation of Factor XI on Activated Platelets Requires the Interaction of Factor XI and Platelet Glycoprotein Ibα with Thrombin Anion-binding Exosites I and II, Respectively. Journal of Biological Chemistry. 278:48112-48119. 2003
- A look-up table for fully developed film-boiling heat transfer. Nuclear Engineering and Design. 225:83-97. 2003
- Roles of Low Specificity and Cofactor Interaction Sites on Thrombin during Factor XIII Activation. Journal of Biological Chemistry. 278:32020-32026. 2003
- Structural requirements for the activation of human factor VIII by thrombin. Blood. 100:2820-2826. 2002
- Immunological Consequences of Topical Bovine Thrombin. American Journal of Pathology. 159:2371-2371. 2001
- An Extensive Interaction Interface between Thrombin and Factor V Is Required for Factor V Activation. Journal of Biological Chemistry. 276:25143-25149. 2001
- A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V. Proceedings of the National Academy of Sciences of the United States of America. 98:1823-1828. 2001
- Identification of Critical Residues on Thrombin Mediating Its Interaction with Fibrin. Thrombosis and Haemostasis. 86:1466-1474. 2001
- Dissociation of Thrombin's Substrate Interactions Using Site-Directed Mutagenesis. Trends in Cardiovascular Medicine. 10:89-92. 2000
- Thrombin Interacts with Thrombomodulin, Protein C, and Thrombin-activatable Fibrinolysis Inhibitor via Specific and Distinct Domains. Journal of Biological Chemistry. 274:25510-25516. 1999
- Senescent human neutrophil binding to thrombospondin (TSP): evidence for a TSP‐independent pathway of phagocytosis by macrophages. British Journal of Haematology. 102:957-964. 1998
- Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties. Cellular and Molecular Life Sciences. 53:731-736. 1997
- A woman who had a stroke, then a myocardial infarction. The Lancet. 349:1218-1218. 1997
- Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils. Journal of Biological Chemistry. 271:15381-15385. 1996
- The 1995 look-up table for critical heat flux in tubes. Nuclear Engineering and Design. 163:1-23. 1996
- Protein Engineering Thrombin for Optimal Specificity and Potency of Anticoagulant Activityin Vivo. Biochemistry. 35:16449-16457. 1996
- A peptide derived from a tissue factor loop region functions as a tissue factor-factor VIIa antagonist. Biochemistry. 34:15328-15333. 1995
- Conversion of thrombin into an anticoagulant by protein engineering. Nature Nature: New biology. 378:413-416. 1995
- Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Usingin VitroGenetics. Journal of Biological Chemistry. 270:19370-19376. 1995
- Functional Mapping of the Surface Residues of Human Thrombin. Journal of Biological Chemistry. 270:16854-16863. 1995
- Histidine-rich glycoprotein: is there a role in hemostasis or immune function?. Journal of Laboratory and Clinical Medicine Translational Research. 125:682-683. 1995
- Involvement of CD31 in lymphocyte-mediated immune responses: importance of the membrane-proximal immunoglobulin domain and identification of an inhibiting CD31 peptide. Blood. 85:1282-1288. 1995
- Identification of the Factor VIIa Binding Site on Tissue Factor by Homologous Loop Swap and Alanine Scanning Mutagenesis. Biochemistry. 33:14003-14010. 1994
- L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits.. Arteriosclerosis and Thrombosis. 14:1529-1533. 1994
- Pilot study of the efficacy of a thrombin inhibitor for use during cardiopulmonary bypass. Annals of Thoracic Surgery. 58:344-350. 1994
- A novel nucleotide-based thrombin inhibitor inhibits clot-bound thrombin and reduces arterial platelet thrombus formation. Blood. 83:677-682. 1994
- The discovery and characterization of a novel nucleotide-based thrombin inhibitor. Gene. 137:25-31. 1993
- The single-stranded DNA aptamer-binding site of human thrombin.. Journal of Biological Chemistry. 268:20808-20811. 1993
- Identification of SVTCG in thrombospondin as the conformation-dependent, high affinity binding site for its receptor, CD36.. Journal of Biological Chemistry. 268:16179-16184. 1993
- In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits. Blood. 81:3271-3276. 1993
- Crystallization of Bacillus subtilis Tryptophanyl-tRNA Synthetase. Journal of Molecular Biology. 230:1089-1090. 1993
- CD36 peptides enhance or inhibit CD36-thrombospondin binding. A two-step process of ligand-receptor interaction.. Journal of Biological Chemistry. 267:18244-18250. 1992
- The cell adhesion molecule CD31 is phosphorylated after cell activation. Down-regulation of CD31 in activated T lymphocytes.. Journal of Biological Chemistry. 267:5243-5249. 1992
- Role of glycoprotein IIa (beta 1 subunit of very late activation antigens) in platelet functions. Blood. 78:2021-2026. 1991
- Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by f.p.l.c. Characterization by monoclonal antibodies and gas-phase sequencing. Biochemical Journal. 279:419-425. 1991
- Roles of thrombin and platelet membrane glycoprotein IIb/IIIa in platelet-subendothelial deposition after angioplasty in an ex vivo whole artery model.. Circulation. 84:1279-1288. 1991
- Epithelial membrane glycoprotein PAS-IV is related to platelet glycoprotein IIIb binding to thrombospondin but not to malaria-infected erythrocytes. Blood. 77:2649-2654. 1991
- Inhibition of platelet functions by a monoclonal antibody (LYP20) directed against a granule membrane glycoprotein (GMP-140/PADGEM). Blood. 77:1734-1739. 1991
- Local delivery of antithrombin agent by an infusion balloon catheter reduces platelet deposition at the site of balloon angioplasty. Coronary Artery Disease. 2:699-706. 1991
- Development of antibodies to thrombin and factor V with recurrent bleeding in a patient exposed to topical bovine thrombin. Blood. 76:2011-2016. 1990
- Effect of platelet release products on cytosolic calcium in cardiac myocytes. Biochemical and Biophysical Research Communications. 170:1121-1127. 1990
- Histidine-rich glycoprotein as a negative acute phase reactant. American Journal of Hematology. 34:149-150. 1990
- A monoclonal antibody (LYP18) directed against the blood platelet glycoprotein IIb/IIIa complex inhibits human melanoma growth in vivo. Blood. 74:909-912. 1989
- Platelet-melanoma cell interaction is mediated by the glycoprotein IIb- IIIa complex. Blood. 74:658-663. 1989
- Histidine-rich glycoprotein blocks T cell rosette formation and modulates both T cell activation and immunoregulation.. Journal of Biological Chemistry. 264:8254-8259. 1989
- Interaction of histidine-rich glycoprotein with human T lymphocytes.. Journal of Biological Chemistry. 264:8249-8253. 1989
- Computation of single- and two-phase heat transfer rates suitable for water-cooled tubes and subchannels. Nuclear Engineering and Design. 114:61-77. 1989
- Rapid purification and partial characterization of human platelet glycoprotein IIIb. Interaction with thrombospondin and its role in platelet aggregation.. Journal of Biological Chemistry. 264:501-506. 1989
- A model for predicting diabatic pressure drops in multi-element fuel channels. Nuclear Engineering and Design. 110:299-312. 1989
- Heparin binds to human monocytes and modulates their procoagulant activities and secretory phenotypes. Effects of histidine-rich glycoprotein. Blood. 73:177-184. 1989
- [23] Platelet histidine-rich glycoprotein. Methods in Enzymology. 169:268-276. 1989
- Two-phase pressure drop through obstructions. Nuclear Engineering and Design. 105:349-361. 1988
- Human brain glial cells synthesize thrombospondin.. Proceedings of the National Academy of Sciences of the United States of America. 83:2904-2908. 1986
- Thrombospondin: a versatile multifunctional glycoprotein.. Arteriosclerosis. 6:245-253. 1986
- Interaction of histidine-rich glycoprotein with fibrinogen and fibrin.. Journal of Clinical Investigation. 77:1305-1311. 1986
- Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex. Blood. 66:926-934. 1985
- Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation.. Journal of Biological Chemistry. 260:10346-10352. 1985
- Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine-rich glycoprotein.. Journal of Clinical Investigation. 75:2065-2073. 1985
- Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.. Journal of Clinical Investigation. 74:1625-1633. 1984
- Role of thrombospondin in platelet aggregation.. Journal of Clinical Investigation. 74:1764-1772. 1984
- Complex formation of platelet membrane glycoproteins IIb and IIIa with the fibrinogen D domain.. Journal of Biological Chemistry. 259:8584-8588. 1984
- Human megakaryocytes. III. Characterization in myeloproliferative disorders. Blood. 63:615-622. 1984
- Complex formation of platelet thrombospondin with histidine-rich glycoprotein.. Journal of Clinical Investigation. 73:5-12. 1984
- Histidine-rich glycoprotein is present in human platelets and is released following thrombin stimulation. Blood. 62:1016-1021. 1983
- Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix.. Proceedings of the National Academy of Sciences of the United States of America. 80:998-1002. 1983
- Effect of flow-obstruction geometry on pressure drops in horizontal air-water flow. International Journal of Multiphase Flow. 9:73-85. 1983
- Complex Formation of Platelet Membrane Glycoproteins IIb and IIIa: A Model of Platelet Activation. Current Studies in Hematology and Blood Transfusion. VOL. 49:127-130. 1983
- Complex formation of platelet thrombospondin with fibrinogen.. Journal of Clinical Investigation. 70:542-549. 1982
- Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen.. Journal of Clinical Investigation. 69:263-269. 1982
- Thrombospondin is the endogenous lectin of human platelets. Nature Nature: New biology. 295:246-248. 1982
- alpha-Actinin and membrane glycoprotein IIIa are different proteins in human blood platelets.. Proceedings of the National Academy of Sciences of the United States of America. 79:432-435. 1982
- Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study.. Journal of Experimental Medicine. 154:1058-1068. 1981
- Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes.. Journal of Experimental Medicine. 154:88-100. 1981
- Isolation, purification, and partial characterization of platelet membrane glycoproteins IIb and IIIa.. Journal of Biological Chemistry. 256:1994-1997. 1981
- EVOLUTION OF THE CANADIAN SCWR FUEL-ASSEMBLY CONCEPT AND ASSESSMENT OF THE 64 ELEMENT ASSEMBLY FOR THERMALHYDRAULIC PERFORMANCE. CNL Nuclear Review. 1-18.
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book
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chapter
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conference paper
- New IAEA Coordinated Research Project on Thermal-Hydraulics of Supercritical Water Cooled Reactors. Volume 2: Smart Grids, Grid Stability, and Offsite and Emergency Power; Advanced and Next Generation Reactors, Fusion Technology; Safety, Security, and Cyber Security; Codes, Standards, Conformity Assessment, Licensing, and Regulatory Issues. 2016
- Experimental Study of Heat Transfer to Supercritical Pressure Water Flowing in a 2×2 Rod Bundle. Volume 2A: Thermal Hydraulics. 2014
- Assessment of Heat-Transfer Correlations Against Experimental Data Obtained With Supercritical Water in Vertical Annuli. Volume 3: Thermal-Hydraulics; Turbines, Generators, and Auxiliaries. 103-110. 2012
- Microfluidic platelet analysis platform based on impedance spectroscopy. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. 1579-1581. 2012
- THERMALHYDRAULICS AND SAFETY PROGRAMS IN SUPPORT OF THE CANDU SCWR DESIGN. PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON NUCLEAR ENGINEERING 2010, VOL 6. 211-218. 2011
- Comparison and Improvements of Correlations for Film Boiling in Tubes. Volume 3: Thermal Hydraulics; Current Advanced Reactors: Plant Design, Construction, Workforce and Public Acceptance. 793-799. 2009
- ANALYTICAL AND EXPERIMENTAL PROGRAM OF SUPERCRITICAL HEAT TRANSFER RESEARCH AT THE UNIVERSITY OF OTTAWA. Nuclear Engineering and Technology. 107-116. 2008
- The 2006 CHF look-up table. Nuclear Engineering and Design. 1909-1922. 2007
- Thermalhydraulics studies examining the feasibility for introducing slightly enriched uranium fuel into the Embalse CANDU reactor. Nuclear Engineering and Design. 1628-1638. 2007
- Modulation of Thrombin’s Procoagulant and Anticoagulant Properties. Thrombosis and Haemostasis. 577-580. 1997
- Application of Combinatorial Libraries and Protein Engineering to the Discovery of Novel Anti-Thrombotic Drugs. Thrombosis and Haemostasis. 373-376. 1995
- Molecular and cellular biology of a major blood platelet glycoprotein (CD36): Interaction CD36-thrombospondin. Nouvelle Revue Francaise d'Hematologie. 143. 1991