Aly-Khan Lalani - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Full-Time Member, Escarpment Cancer Research Institute (ECRI), Faculty of Health Sciences
Assistant Professor, Oncology, Faculty of Health Sciences
Staff Medical Oncologist, Juravinski Cancer Centre,
Chair, Genitourinary Cancers Disease Site Team, Juravinski Cancer Centre,

Research Areas

Cancer (RA)
Cancer drug development and therapeutics (RA)
Microbiome (RA)

Scholarly Activity in McMaster Experts

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co-investigator network

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selected scholarly activity

academic article
- Emerging Biomarkers of Response to Systemic Therapies in Metastatic Clear Cell Renal Cell Carcinoma. Hematology / Oncology Clinics of North America. 37:937-942. 2023
- How I Do It: Maintenance avelumab for advanced urothelial carcinoma.. Canadian Journal of Urology. 30:11633-11638. 2023
- Comparison of patients with renal cell carcinoma in adjuvant therapy trials to a real-world population. Urologic Oncology: seminars and original investigations. 41:328.e15-328.e23. 2023
- Optimizing Treatment Selection in Advanced Renal Cell Carcinoma via IMDC Risk Group Stratification. European Urology. S0302-2838(23)02959-7. 2023
- Outcomes for International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Groups in Contemporary First-line Combination Therapies for Metastatic Renal Cell Carcinoma. European Urology. 84:109-116. 2023
- Corrigendum to “Outcomes for International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Groups in Contemporary First-line Combination Therapies for Metastatic Renal Cell Carcinoma” [Eur Urol 2023]. European Urology. 83:e166-e167. 2023
- Real-world outcomes among patients with advanced/metastatic renal cell carcinoma (mRCC) treated with cabozantinib or other tyrosine kinase inhibitors (TKIs) after checkpoint inhibitor (CPI) therapy.. Journal of Clinical Oncology. 41:4530-4530. 2023
- Adjuvant therapy for renal cell carcinoma. Journal of the Canadian Urological Association. 17:E154-63. 2023
- MP41-03 IS A RENAL TUMOUR BENIGN OR MALIGNANT? A PREDICTION TOOL INCLUDING PATIENTS MANAGED WITH SURGERY, ABLATION, OR SURVEILLANCE. Investigative Urology. 209:e555. 2023
- PD07-10 OUTCOMES OF PARTIAL NEPHRECTOMY FOR NON-METASTATIC cT2 RENAL TUMORS: RESULTS FROM A CANADIAN MULTI-INSTITUTIONAL COLLABORATIVE. Investigative Urology. 209:e166. 2023
- Evaluating the impact of early identification of asymptomatic brain metastases in metastatic renal cell carcinoma. Cancer Reports. 6:e1763. 2023
- Outcomes of partial nephrectomy for non-metastatic cT2 renal tumors: Results from a Canadian multi-institutional collaborative.. Journal of Clinical Oncology. 41:690-690. 2023
- Phase II trial of cytoreductive stereotactic hypofractionated radiotherapy with combination ipilimumab/nivolumab for metastatic kidney cancer (CYTOSHRINK).. Journal of Clinical Oncology. 41:TPS750-TPS750. 2023
- The emerging landscape of neo/adjuvant immunotherapy in renal cell carcinoma. Human Vaccines and Immunotherapeutics. 19:2178217. 2023
- CO107 Clinical Outcomes of Patients With Metastatic Renal Cell Carcinoma (MRCC) With or Without Sarcomatoid Differentiation Treated With Systemic Therapy in Real-World Canadian Setting. Value in Health. 25:S39-S39. 2022
- CO177 Association Between the Sarcomatoid Status and Percentage of Sarcomatoid on the Clinical Outcomes of Localized Renal Cell Carcinoma Post Nephrectomy. Value in Health. 25:S52-S52. 2022
- Next Wave of Targets in the Treatment of Advanced Renal Cell Carcinoma. Current Oncology. 29:5426-5441. 2022
- Emerging Biomarker-Guided Therapies in Prostate Cancer. Current Oncology. 29:5054-5076. 2022
- Outcomes of Radiation Therapy Plus Immunotherapy in Metastatic Renal Cell Carcinoma: Results From the Canadian Kidney Cancer Information System. Advances in Radiation Oncology. 7:100899-100899. 2022
- Evolving landscape of first-line combination therapy in advanced renal cancer: a systematic review. Therapeutic Advances in Medical Oncology. 14:175883592211086-175883592211086. 2022
- Utilization and Safety of Ipilimumab Plus Nivolumab in a Real-World Cohort of Metastatic Renal Cell Carcinoma Patients. Clinical Genitourinary Cancer. 20:210-218. 2022
- Association of Neutrophil-to-Lymphocyte Ratio with Efficacy of First-Line Avelumab plus Axitinib vs. Sunitinib in Patients with Advanced Renal Cell Carcinoma Enrolled in the Phase 3 JAVELIN Renal 101 Trial. Clinical Cancer Research. 28:738-747. 2022
- The perceptions and beliefs of cannabis use among Canadian genitourinary cancer patients. Journal of the Canadian Urological Association. 16:48-54. 2022
- Clinical Outcomes and Adverse Events after First-Line Treatment in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis. Investigative Urology. 207:16-24. 2022
- Defining unique clinical hallmarks for immune checkpoint inhibitor-based therapies. Journal for ImmunoTherapy of Cancer. 10:e003024-e003024. 2022
- Active Surveillance in Metastatic Renal Cell Carcinoma: Results From the Canadian Kidney Cancer Information System. Clinical Genitourinary Cancer. 19:521-530. 2021
- The emerging treatment landscape of advanced urothelial carcinoma. Current Opinion in Supportive and Palliative Care. 15:247-252. 2021
- Canadian consensus forum of key controversial areas in the management of advanced prostate cancer. Journal of the Canadian Urological Association. 15:353-358. 2021
- Cytoreductive stereotactic body radiotherapy (SBRT) and combination SBRT with immune checkpoint inhibitors (ICIs) in metastatic renal cell carcinoma. Journal of the Canadian Urological Association. 15:281-286. 2021
- Assessment of Immune Checkpoint Inhibitors and Genomic Alterations by Body Mass Index in Advanced Renal Cell Carcinoma. JAMA Oncology. 7:773-773. 2021
- Management of advanced kidney cancer: Kidney Cancer Research Network of Canada (KCRNC) consensus update 2021. Journal of the Canadian Urological Association. 15:84-97. 2021
- Cabozantinib real‐world effectiveness in the first‐through fourth‐line settings for the treatment of metastatic renal cell carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium. Cancer Medicine. 10:1212-1221. 2021
- Genomic and Clinical Correlates of Adrenocortical Carcinoma in an Adult Patient with Li-Fraumeni Syndrome: A Case Report. Current Oncology. 28:226-232. 2020
- Outcomes in Black and White Patients With Metastatic Renal Cell Carcinoma Treated With First-Line Tyrosine Kinase Inhibitors: Insights From Two Large Cohorts. JCO Global Oncology. 6:293-306. 2020
- Circulating Tumor DNA Alterations in Advanced Urothelial Carcinoma and Association with Clinical Outcomes: A Pilot Study. European Urology Oncology. 3:695-699. 2020
- 211: Outcomes of Radiotherapy Plus Immunotherapy in Metastatic Renal Cell Carcinoma: Results from the Canadian Kidney Cancer Information System (CKCIS). Radiotherapy and Oncology. 150:S89-S90. 2020
- Activity of cabozantinib after immune checkpoint blockade in metastatic clear-cell renal cell carcinoma. European Journal of Cancer. 135:203-210. 2020
- Fourth-Line Therapy in Metastatic Renal Cell Carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC). Kidney Cancer. 4:119-119. 2020
- Effect of Antibiotic Use on Outcomes with Systemic Therapies in Metastatic Renal Cell Carcinoma. European Urology Oncology. 3:372-381. 2020
- Prioritizing systemic therapies for genitourinary malignancies: Canadian recommendations during the COVID-19 pandemic. Journal of the Canadian Urological Association. 14:E154-E158. 2020
- Outcomes of trimodality bladder-sparing therapy for muscle-invasive bladder cancer. Journal of the Canadian Urological Association. 14:123-130. 2020
- Controversial issues in the management of patients with advanced prostate cancer: Results from a Canadian consensus forum. Journal of the Canadian Urological Association. 14:E137-E149. 2020
- Continuing towards optimization of bladder cancer care in Canada: Summary of the 3rd Bladder Cancer Canada-Canadian Urological Association- Canadian Urologic Oncology Group (BCC-CUA-CUOG) bladder cancer quality of care consensus meeting. Journal of the Canadian Urological Association. 14:E115-E125. 2020
- Real-world evidence of cabozantinib in metastatic renal-cell carcinoma (mRCC): Results from the Canadian Kidney Cancer Information System (CKCis).. Journal of Clinical Oncology. 38:682-682. 2020
- From Famine to Feast: Treating Urinary Malignancies in the Immunotherapy Era. European Urology Focus. 6:1-2. 2020
- State of the Future: Translational Approaches in Renal Cell Carcinoma in the Immunotherapy Era. European Urology Focus. 6:37-40. 2020
- Response of Primary Renal Cell Carcinoma to Systemic Therapy. European Urology. 76:852-860. 2019
- Capturing recurrence in urothelial carcinoma: “more than meets the eye”. Translational Andrology and Urology. 8:S524-S527. 2019
- Management of Advanced Kidney Cancer: Kidney Cancer Research Network of Canada (KCRNC) consensus update 2019. Journal of the Canadian Urological Association. 13:343-54. 2019
- Metabolomic adaptations and correlates of survival to immune checkpoint blockade. Nature Communications. 10:4346. 2019
- Kidney Cancer Research Network of Canada (KCRNC) consensus statement on the role of cytoreductive nephrectomy for patients with metastatic renal cell carcinoma. Journal of the Canadian Urological Association. 13:166-174. 2019
- Systemic Treatment of Metastatic Clear Cell Renal Cell Carcinoma in 2018: Current Paradigms, Use of Immunotherapy, and Future Directions. European Urology. 75:100-110. 2019
- Systemic treatments for metastatic urothelial carcinoma. Expert Opinion on Pharmacotherapy. 20:201-208. 2019
- Change in neutrophil-to-lymphocyte ratio (NLR) in response to immune checkpoint blockade for metastatic renal cell carcinoma. Journal for ImmunoTherapy of Cancer. 6:5. 2018
- Everolimus and pazopanib (E/P) benefit genomically selected patients with metastatic urothelial carcinoma. British Journal of Cancer. 119:707-712. 2018
- The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma. Cancer immunology research. 6:758-765. 2018
- Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2). British Journal of Cancer. 118:1434-1441. 2018
- Targeted genomic landscape of metastases compared to primary tumours in clear cell metastatic renal cell carcinoma. British Journal of Cancer. 118:1238-1242. 2018
- Durable Clinical Benefit in Metastatic Renal Cell Carcinoma Patients Who Discontinue PD-1/PD-L1 Therapy for Immune-Related Adverse Events. Cancer immunology research. 6:402-408. 2018
- Fourth-Line Therapy in Metastatic Renal Cell Carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC)1. Kidney Cancer. 2:31-36. 2018
- Antibiotic use and outcomes with systemic therapy in metastatic renal cell carcinoma (mRCC).. Journal of Clinical Oncology. 36:607-607. 2018
- JAVELIN: avelumab another spear to fight urothelial carcinoma. The Lancet Oncology. 19:5-7. 2018
- Proton Pump Inhibitors and Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma. Clinical Genitourinary Cancer. 15:724-732. 2017
- Response to single agent PD-1 inhibitor after progression on previous PD-1/PD-L1 inhibitors: a case series. Journal for ImmunoTherapy of Cancer. 5:66. 2017
- Upper Tract Urothelial Carcinomas: Prognostic Factors and Outcomes in Patients With Non–Lymph Node Distant Metastasis. Clinical Genitourinary Cancer. 15:e1089-e1094. 2017
- Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma and its association with PD-L1 expression. Oncotarget. 8:103428-103436. 2017
- Immunotherapy in the Elderly. European Urology Focus. 3:403-412. 2017
- Change in neutrophil-to-lymphocyte ratio (NLR) in response to immunotherapy for metastatic renal cell carcinoma (mRCC). Annals of Oncology. 28:v314-v315. 2017
- Pan-urologic cancer genomic subtypes that transcend tissue of origin. Nature Communications. 8:199. 2017
- Differential expression of c-Met between primary and metastatic sites in clear-cell renal cell carcinoma (ccRCC) and its association with PD-L1 expression.. Journal of Clinical Oncology. 35:4573-4573. 2017
- Outcomes of women with small, early-stage breast cancer in Manitoba from 2006-2011.. Journal of Clinical Oncology. 35:e12000-e12000. 2017
- Proton pump inhibitors (PPIs) and survival outcomes in patients with metastatic renal cell carcinoma (mRCC).. Journal of Clinical Oncology. 35:493-493. 2017
- First-line sunitinib or pazopanib in metastatic renal cell carcinoma: The Canadian experience. Journal of the Canadian Urological Association. 11:112-112. 2017
- Manifestations of Von Hippel Lindau syndrome: a retrospective national review. QJM: an international journal of medicine. 107:291-296. 2014
- Can incomplete metastasectomy impact renal cell carcinoma outcomes? A propensity score matching analysis from a prospective multicenter collaboration. Société Internationale d’Urologie Journal. 2:82-95.
conference paper
- Patients from Institutions with a Low pT2 Call Rate in Clear Cell Renal Cell Carcinoma may Experience Lower Stage-Specific Recurrence and Death. Laboratory Investigation. S1698-S1699. 2023
- ASSOCIATION BETWEEN THE SARCOMATOID STATUS AND PERCENTAGE OF SARCOMATOID ON THE CLINICAL OUTCOMES OF LOCALIZED RENAL CELL CARCINOMA POST NEPHRECTOMY. Value in Health. S52-S52. 2022
- CLINICAL OUTCOMES OF PATIENTS WITH METASTATIC RENAL CELL CARCINOMA (MRCC) WITH OR WITHOUT SARCOMATOID DIFFERENTIATION TREATED WITH SYSTEMIC THERAPY IN REAL-WORLD CANADIAN SETTING. Value in Health. S39-S39. 2022
- The impact of impaired renal function on the effectiveness of first-line immuno-oncology combination therapies in metastatic renal cell carcinoma (mRCC): Results from the international metastatic RCC database consortium (IMDC). Annals of Oncology. S660-S680. 2022
- 1464P The impact of impaired renal function on the effectiveness of first-line immuno-oncology combination therapies in metastatic renal cell carcinoma (mRCC): Results from the international metastatic RCC database consortium (IMDC). Annals of Oncology. S1215-S1216. 2022
- Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet Oncology. 1133-1144. 2022
- Significant variation of tumour stage by size in clear cell renal cell carcinoma from a prospective national database with a sub-analysis for causality. Virchows Archiv: an international journal of pathology. S351-S352. 2022
- OUTCOMES OF PARTIAL NEPHRECTOMY FOR NON-METASTATIC CT2 RENAL TUMORS: RESULTS FROM A CANADIAN MULTI-INSTITUTIONAL COLLABORATIVE. The Journal of Urology. E394-E394. 2022
- Association of cabozantinib dose reductions for toxicity with clinical effectiveness in metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer Information System (CKCis).. Journal of Clinical Oncology. 316-316. 2022
- Effectiveness of first-line therapy in patients with advanced non-clear renal cell carcinoma (nccRCC).. Journal of Clinical Oncology. 304-304. 2022
- Phase II trial of cytoreductive stereotactic hypofractionated radiotherapy with combination ipilimumab/nivolumab for metastatic kidney cancer (CYTOSHRINK).. Journal of Clinical Oncology. TPS398-TPS398. 2022
- Effectiveness of first-line therapy in patients with advanced non-clear renal cell carcinoma.. Journal of Clinical Oncology. 2022
- Phase II trial of cytoreductive stereotactic hypofractionated radiotherapy with combination ipilimumab/nivolumab for metastatic kidney cancer (CYTOSHRINK). Journal of Clinical Oncology. 2022
- Outcomes of Radiation Therapy Plus Immunotherapy in Metastatic Renal Cell Carcinoma: Results From the Canadian Kidney Cancer Information System. Advances in Radiation Oncology. 2022
- PD40-07 CLINICAL OUTCOMES AND ADVERSE EVENTS AFTER FIRST-LINE TREATMENT IN METASTATIC RENAL CELL CARCINOMA: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. Investigative Urology. 2021
- Real-Word Experience of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC): Results from the Canadian Kidney Cancer information system (CKCis). Kidney Cancer. 21-29. 2021
- Outcomes of Radiotherapy Plus Immunotherapy in Metastatic Renal Cell Carcinoma: Results From The Canadian Kidney Cancer Information System (CKCis). International Journal of Radiation: Oncology - Biology - Physics. e887-e887. 2020
- Sites of metastasis and survival in metastatic renal-cell carcinoma (mRCC): Resuits from the international mRCC Database Consortium (IMDC). Asia Pacific Journal of Clinical Oncology. 4-4. 2020
- Abstract NG13: Metabolomic adaptations and correlates of survival to immune checkpoint blockade. Cancer Research. NG13-NG13. 2020
- Cabozantinib real-world effectiveness in the first through fourth-line settings for the treatment of metastatic renal cell carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC). Journal of Clinical Oncology. 2020
- Cabozantinib real-world effectiveness in the first through fourth-line settings for the treatment of metastatic renal cell carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC).. Journal of Clinical Oncology. 639-639. 2020
- Impact of early identification of brain metastases in metastatic renal cell carcinoma (mRCC). Journal of Clinical Oncology. 2020
- Impact of early identification of brain metastases in metastatic renal cell carcinoma (mRCC).. Journal of Clinical Oncology. 620-620. 2020
- Phase II trial of cytoreductive stereotactic hypofractionated radiotherapy with combination ipilimumab/nivolumab for metastatic kidney cancer (CYTOSHRINK). Journal of Clinical Oncology. 2020
- Phase II trial of cytoreductive stereotactic hypofractionated radiotherapy with combination ipilimumab/nivolumab for metastatic kidney cancer (CYTOSHRINK).. Journal of Clinical Oncology. TPS761-TPS761. 2020
- Real-world evidence of cabozantinib in metastatic renal-cell carcinoma (mRCC): Results from the Canadian Kidney Cancer Information System (CKCis). Journal of Clinical Oncology. 2020
- Real-world utilization and safety of ipilimumab plus nivolumab (I plus N) in metastatic renal cell carcinoma (mRCC) patients: Results from the Canadian Kidney Cancer Information System (CKCis). Journal of Clinical Oncology. 2020
- Real-world utilization and safety of ipilimumab plus nivolumab (I+N) in metastatic renal cell carcinoma (mRCC) patients: Results from the Canadian Kidney Cancer Information System (CKCis).. Journal of Clinical Oncology. 633-633. 2020
- Sites of metastasis and survival in metastatic renal cell carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC). Journal of Clinical Oncology. 2020
- Sites of metastasis and survival in metastatic renal cell carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC).. Journal of Clinical Oncology. 642-642. 2020
- CCTG IND 232: A phase II study of durvalumab with or without tremelimumab in patients with metastatic castration resistant prostate cancer (mCRPC). Annals of Oncology. 885-885. 2019
- CCTG IND 232: A phase II study of durvalumab with or without tremelimumab in patients with metastatic castration resistant prostate cancer (mCRPC). Annals of Oncology. v885-v885. 2019
- Efficacy of immune checkpoint inhibitors (ICI) and genomic alterations by body mass index (BMI) in advanced renal cell carcinoma (RCC). Annals of Oncology. 396-396. 2019
- Efficacy of immune checkpoint inhibitors (ICI) and genomic alterations by body mass index (BMI) in advanced renal cell carcinoma (RCC). Annals of Oncology. v396-v396. 2019
- Active surveillance in metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer information system (CKCis).. Journal of Clinical Oncology. 4516-4516. 2019
- Efficacy of targeted therapy (TT) after checkpoint inhibitors (CPI) in metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer Information System (CKCis).. Journal of Clinical Oncology. 568-568. 2019
- Impact of body mass index (BMI) on treatment outcomes to immune checkpoint blockade (ICB) in metastatic renal cell carcinoma (mRCC).. Journal of Clinical Oncology. 566-566. 2019
- Activity of cabozantinib (cabo) after PD-1/PD-L1 immune checkpoint blockade (ICB) in metastatic clear cell renal cell carcinoma (mccRCC). Annals of Oncology. viii311-viii311. 2018
- CD73 expression in primary and metastatic renal cell carcinoma (RCC).. Journal of Clinical Oncology. 643-643. 2018
- Genomic alterations to refine prognostication of patients with metastatic renal cell carcinoma.. Journal of Clinical Oncology. 626-626. 2018
- Impact of tumor size on survival outcome in metastatic renal cell carcinoma patients (mRCC) treated with targeted therapy.. Journal of Clinical Oncology. 667-667. 2018
- Renal cell carcinoma (RCC) primary tumor shrinkage on vascular endothelial growth factor (VEGF)-targeted therapy (TT): A pooled analysis.. Journal of Clinical Oncology. 629-629. 2018
- Clinical outcomes according to ethnicity in patients with metastatic renal cell carcinoma (mRCC) treated with VEGF-targeted therapy (TT).. Journal of Clinical Oncology. e16065-e16065. 2017
- Individualized treatment with sunitinib versus standard dosing with sunitinib or pazopanib in patients with metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer information system (CKCis).. Journal of Clinical Oncology. e16078-e16078. 2017
- Individualized treatment with sunitinib versus standard dosing with sunitinib or pazopanib in patients with metastatic renal cell carcinoma (mRCC): Results from the Canadian Kidney Cancer information system (CKCis).. Journal of Clinical Oncology. 468-468. 2017
- Proton-pump inhibitors and survival outcomes in patients with metastatic renal cell carcinoma. BJU International. 7-7. 2016
- Real world outcomes of patients with metastatic renal cell carcinoma (mRCC) using first-line sunitinib or pazopanib: the Canadian experience. Annals of Oncology. vi285-vi285. 2016
- Abstract P3-07-13: Outcomes of women with small, early-stage breast cancer in Manitoba from 1995-2011. Cancer Research. p3-07-13-p3-07-13. 2015
- Outcomes of women with small, early-stage breast cancer in Manitoba from 1995-2011. Cancer Research. 2015
- Optimizing the travel experiences of children and families during flight.. Journal of Investigative Medicine. S173-S173. 2006