Journal article
Regulation of Myogenic Differentiation by Androgens: Cross Talk between Androgen Receptor/ β-Catenin and Follistatin/Transforming Growth Factor-β Signaling Pathways
Abstract
Androgens are important regulators of body composition and promote myogenic differentiation and inhibit adipogenesis of mesenchymal, multipotent cells. Here, we investigated the mechanisms by which androgens induce myogenic differentiation of mesenchymal multipotent cells. Incubation of mesenchymal multipotent C3H 10T1/2 cells with testosterone and dihydrotestosterone promoted nuclear translocation of androgen receptor (AR)/beta-catenin complex …
Authors
Singh R; Bhasin S; Braga M; Artaza JN; Pervin S; Taylor WE; Krishnan V; Sinha SK; Rajavashisth TB; Jasuja R
Journal
Endocrinology, Vol. 150, No. 3, pp. 1259–1268
Publisher
The Endocrine Society
Publication Date
March 1, 2009
DOI
10.1210/en.2008-0858
ISSN
0013-7227
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AndrogensAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell DifferentiationCell NucleusCells, CulturedFollistatinMaleMiceMice, Inbred C57BLMuscle DevelopmentNerve Tissue ProteinsOrchiectomyProtein TransportRNA, Small InterferingReceptor Cross-TalkReceptors, AndrogenSignal TransductionTCF Transcription FactorsTranscription Factor 4Transforming Growth Factor betabeta Catenin