Journal article
Effects of inhaled nitric oxide in a rat model of Pseudomonas aeruginosa pneumonia
Abstract
OBJECTIVE: Antimicrobial effects of nitric oxide (NO) have been demonstrated in vitro against a variety of infectious pathogens, yet in vivo evidence of a potential therapeutic role for exogenous NO as an antimicrobial agent is limited. Thus, we assessed the effects of inhaled NO on pulmonary infection, leukocyte infiltration, and NO synthase (NOS) activity in a rat model of Pseudomonas aeruginosa pneumonia.
DESIGN: Controlled animal study.
Authors
Webert KE; Vanderzwan J; Duggan M; Scott JA; McCormack DG; Lewis JF; Mehta S
Journal
Critical Care Medicine, Vol. 28, No. 7, pp. 2397–2405
Publisher
Wolters Kluwer
Publication Date
July 2000
DOI
10.1097/00003246-200007000-00035
ISSN
0090-3493