Measurement of Water Turnover Using Deuterium Dilution: Impact of Periodically Varying Turnover Rates on Precision and Accuracy

Water metabolism may be non-invasively investigated using deuterium elimination from the body. Evaluation of elimination constants (kD) and pool sizes (N) becomes complicated when turnover rates vary periodically--a realistic scenario in free-living subjects. Unfortunately, phase and frequency of periodic variations are not a priori known and can therefore not be used for a sampling protocol. This study investigates the impact of periodical …