Evaluating the benefit of event adjudication of cardiovascular outcomes in large simple RCTs

BACKGROUND: Event adjudication in randomized controlled trials is thought to be a necessary step to remove noise and potential bias from the results [1,2]. However, this hypothesis has not been widely evaluated. We conducted a meta-analysis of a series of cardiovascular outcomes trials and estimated the effect of adjudication on treatment estimates and on the number of outcomes included the trials. METHODS: Data were retrieved from all …