Analysing recurrent hospitalizations in heart failure: a review of statistical methodology, with application to CHARM‐Preserved

AIMS: Heart failure is characterized by recurrent hospitalizations, but often only the first event is considered in clinical trial reports. In chronic diseases, such as heart failure, analysing all events gives a more complete picture of treatment benefit. We describe methods of analysing repeat hospitalizations, and illustrate their value in one major trial. METHODS AND RESULTS: The Candesartan in Heart failure Assessment of Reduction in …