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Haemoglobin Q‐Thailand and hereditary...

Journal article

Haemoglobin Q‐Thailand and hereditary spherocytosis in a Chinese family

Abstract

A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.

Authors

Leung KFS; Au WY; Chan AYY; Chan LC; Waye JS; Chui DHK; Ma SK

Journal

International Journal of Laboratory Hematology, Vol. 23, No. 1, pp. 53–55

Publisher

Wiley

Publication Date

February 6, 2001

DOI

10.1046/j.1365-2257.2001.00349.x

ISSN

1751-5521

Associated Experts

David Hing-kwei Chui

Professor Emeritus, Faculty of Health Sciences

John Waye

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

32 Biomedical and Clinical Sciences 3201 Cardiovascular medicine and haematology

Medical Subject Headings (MeSH)

Adult Anemia, Hemolytic, Congenital China Family Health Female Genotype Hemoglobins, Abnormal Heterozygote Humans Nuclear Family Osmotic Fragility Pedigree Phenotype Spherocytosis, Hereditary

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