Journal article
Transection of dysmyelinated optic nerve axons in adult rats lacking myelin basic protein
Abstract
Injury to myelin or oligodendrocytes may manifest as dysmyelinating or demyelinating conditions of the CNS. Previous studies using dysmyelinated animal models (myelin basic protein mutants) suggest possible axonal dysfunction with complete loss of myelin. In this present study, we evaluated retinal ganglion cell survival after axotomy in MBP mutants to determine if prolonged dysmyelination of CNS axons exerted a detrimental effect on neuronal …
Authors
Phokeo V; Ball AK
Journal
Neuroreport, Vol. 11, No. 15, pp. 3375–3379
Publisher
Wolters Kluwer
Publication Date
October 2000
DOI
10.1097/00001756-200010200-00022
ISSN
0959-4965