Journal article
Integrated fragmentation of human IgG and purification of Fab using a reactant adsorptive membrane bioreactor separator system
Abstract
This article discusses an integrated separation-reaction-separation scheme for producing Fab fragment directly from human immunoglobulin G (hIgG) present in serum feed. The novel reactant adsorptive membrane bioreactor separator (or RAMBS) system used in the current study consisted of a stack of microporous adsorptive membranes held within a temperature controlled module. The membrane stack, in the presence of salt, selectively and reversibly …
Authors
Yu D; Ghosh R
Journal
Biotechnology and Bioengineering, Vol. 104, No. 1, pp. 152–161
Publisher
Wiley
Publication Date
9 2009
DOI
10.1002/bit.22362
ISSN
0006-3592