Journal article
In vitro effects of melatonin on [3H]muscimol binding in rat brain
Abstract
The possible interaction of melatonin with the GABAergic system at the receptor level was investigated. The effect of melatonin on the binding of the GABA agonist, [3H]muscimol, in crude synaptic membrane preparations was assayed. In fresh membrane preparations, melatonin increased [3H]muscimol binding in the rat striatum and frontal cortex. Treatment of membrane preparations with Triton X-100 appeared to abolish or depress the enhancing effect …
Authors
Coloma FM; Niles LP
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 8, No. 4-6, pp. 669–672
Publisher
Elsevier
Publication Date
January 1984
DOI
10.1016/0278-5846(84)90034-4
ISSN
0278-5846