Journal article
Allosteric modulation of t-[35S]butylbicyclophosphorothionate binding in rat brain by melatonin
Abstract
In order to clarify melatonin's pharmacological interaction with central gamma-aminobutyric acid (GABA) receptors, its effects on the binding of t-[35S]butylbicyclophosphorothionate ([35S]TBPS), which specifically labels GABA-gated chloride channels, was examined in the rat brain. Saturation binding studies indicated that the effect of melatonin (500 microM) was due to a significant decrease in binding site density (Bmax) while the dissociation …
Authors
Niles LP; Peace CH
Journal
Brain Research Bulletin, Vol. 24, No. 4, pp. 635–638
Publisher
Elsevier
Publication Date
April 1990
DOI
10.1016/0361-9230(90)90171-u
ISSN
0361-9230