Journal article
Extracellular Signal-Regulated Kinase 2 and CHOP Restrict the Expression of the Growth Arrest-Specific p20K Lipocalin Gene to G0
Abstract
The activation of the growth arrest-specific (gas) p20K gene depends on the interaction of C/EBPβ with two elements of a 48-bp promoter region termed the quiescence-responsive unit (QRU). Here we identify extracellular signal-related kinase 2 (ERK2) as a transcriptional repressor of the p20K QRU in cycling chicken embryo fibroblasts (CEF). ERK2 binds to repeated GAAAG sequences overlapping the C/EBPβ sites of the QRU. The recruitment of ERK2 …
Authors
Erb MJ; Camacho D; Xie W; Maslikowski BM; Fielding B; Ghosh R; Poujade F-A; Athar M; Assee S; Mantella L-E
Journal
Molecular and Cellular Biology, Vol. 36, No. 23, pp. 2890–2902
Publisher
Taylor & Francis
Publication Date
December 1, 2016
DOI
10.1128/mcb.00338-16
ISSN
0270-7306
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAvian ProteinsCCAAT-Enhancer-Binding Protein-betaCell CycleCell HypoxiaCell ProliferationCells, CulturedChick EmbryoEndoplasmic Reticulum StressFibroblastsGene Expression ProfilingGene Expression RegulationLipocalinsMitogen-Activated Protein Kinase 1Promoter Regions, GeneticTranscription Factor CHOP