Journal article
T cell–mediated exocrine pancreatic damage in major histocompatibility complex class II–deficient mice
Abstract
BACKGROUND & AIMS: Recent observations suggest a role for lymphocytes in human pancreatitis. However, existing animal models of pancreatitis are not immunologically based. In studies on major histocompatibility complex (MHC) II-deficient mice backcrossed five generations onto a C57BL/6 background, we discovered a progressive wasting disease due to pancreatic damage. The purpose of this study was to characterize this model of immune-based …
Authors
Vallance BA; Hewlett BR; Snider DP; Collins SM
Journal
Gastroenterology, Vol. 115, No. 4, pp. 978–987
Publisher
Elsevier
Publication Date
10 1998
DOI
10.1016/s0016-5085(98)70270-7
ISSN
0016-5085