Journal article
Differential Toxicity of Cis and Trans Isomers of Dichlorodiammineplatinum
Abstract
Nephrotoxicity is the dose-limiting toxic effect of cis-dichlorodiammineplatinum (cis-platin) in humans. Its stereoisomer transplatin does not have any toxicity at equimolar concentrations, and it also possesses little antitumor activity. In this study, subcellular localization of both the platinum isomers was examined in the liver and kidney of the mouse 24 hours following the drug administration. Levels of the platinum isomers were measured …
Authors
Singh G; Koropatnick J
Journal
Journal of Biochemical and Molecular Toxicology, Vol. 3, No. 3, pp. 223–233
Publisher
Wiley
Publication Date
9 1988
DOI
10.1002/jbt.2570030308
ISSN
1095-6670