Journal article
The effect of intracellular pH on long-chain fatty acid uptake in 3T3-L1 adipocytes: evidence that uptake involves the passive diffusion of protonated long-chain fatty acids across the plasma membrane
Abstract
To understand the mechanism of long-chain fatty acid permeation of the plasma membrane in mammalian cells, the effects of changes in the cytoplasmic pH on the internalization of physiologically relevant, submicromolar concentrations of uncomplexed long-chain fatty acids were investigated in 3T3-L1 adipocytes. The acidification of the cytoplasm upon NH4Cl prepulsing of intact cells was accompanied by a rapid reduction of cellular long-chain …
Authors
TRIGATTI BL; GERBER GE
Journal
Biochemical Journal, Vol. 313, No. 2, pp. 487–494
Publisher
Portland Press
Publication Date
January 15, 1996
DOI
10.1042/bj3130487
ISSN
0264-6021