Journal article
Control of protein expression through mRNA stability in calcium signalling
Abstract
Specific sequences (cis-acting elements) in the 3'-untranslated region (UTR) of RNA, together with stabilizing and destabilizing proteins (trans-acting factors), determine the mRNA stability, and consequently, the level of expression of several proteins. Such interactions were discovered initially for short-lived mRNAs encoding cytokines and early genes like c-jun and c-myc. However, they may also determine the fate of more stable mRNAs in a …
Authors
Misquitta CM; Chen T; Grover AK
Journal
Cell Calcium, Vol. 40, No. 4, pp. 329–346
Publisher
Elsevier
Publication Date
October 2006
DOI
10.1016/j.ceca.2006.04.004
ISSN
0143-4160
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3' Untranslated RegionsAnimalsCalciumCalcium SignalingCardiac Output, LowELAV ProteinsGene Expression RegulationHeterogeneous Nuclear Ribonucleoprotein D0Heterogeneous-Nuclear Ribonucleoprotein DNucleic Acid ConformationProtein Modification, TranslationalProteinsRNA StabilityRNA, MessengerSarcoplasmic Reticulum Calcium-Transporting ATPases