Structural Determinants Responsible for the Biological Activity of (-)-Emetine, (-)-Cryptopleurine, and (-)-Tylocrebrine: Structure-Activity Relationship among Related Compounds

The structural basis for the cross-resistance and the common site of action of the benzoiosoquinoline alkaloids, (-)-emetine, (-)-tubulosine, (-)-cephaeline, and (-)-dehydroemetine, and of the phenanthroquinolizidine-type alkaloids, (-)-cryptopleurine, and the phenanthroindolizidine type, (-)-tylocrebrine, has been investigated by examining the cross-resistance of emetine-resistant mutants of Chinese hamster ovary cells to a large number of …