Journal article
Mutagenic responses of five independent geentic loci in CHO cells to a variety of mutagens Development and characteristics of a mutagen screening system based on selection of multiple drug-resistant markers
Abstract
With the aim of developing a sensitive mutagen screening system, the responses of 15 different chemical mutagens at 5 independent genetic loci in Chinese hamster ovary (CHO) cells have been determined. The genetic markers which have been employed include resistance to thioguanine (Thgr), ouabain (OuaR), the protein synthesis inhibitor emetine (Emtr), the polyamine synthesis inhibitor methylglyoxal bisguanylhydrazone (Mbgr) and the nucleoside …
Authors
Gupta RS; Singh B
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 94, No. 2, pp. 449–466
Publisher
Elsevier
Publication Date
June 1982
DOI
10.1016/0027-5107(82)90307-4
ISSN
0027-5107