Journal article
Absence of gene amplification in human cell mutants resistant to cardiac glycosides
Abstract
In HeLa cells, four different types of mutants resistant to cardiac glycosides viz. ouabain and SC4453, which differ from each other in cross resistance pattern, have been isolated after single-step selections [J Biol Chem 260 (1985) 6843–6850; J Biol Chem 261 (1986) 2034–2040]. Using cloned cDNA probes specific for the α and β subunits of Na+/K+ ATPase, these mutants have been investigated for amplification and/or increased transcription of …
Authors
Dudani AK; Gupta RS
Journal
Molecular and Cellular Biochemistry, Vol. 78, No. 1, pp. 73–79
Publisher
Springer Nature
Publication Date
11 1987
DOI
10.1007/bf00224426
ISSN
0300-8177