Journal article
In Vitro Effects of Budesonide on Eosinophil-Basophil Lineage Commitment
Abstract
IL-5 is the primary cytokine that stimulates the production and survival of eosinophils and basophils from progenitor cells. The inhaled glucocorticoid, budesonide, has been shown to exert a therapeutic effect via suppression of eosinophil/basophil progenitors in vivo. Since various steroids have exhibited the ability to enhance eosinophil/basophil progenitor differentiation, we examined the effects of budesonide in vitro. Bone marrow and cord …
Authors
Cyr MM; Baatjes AJ; Dorman SC; Crawford L; Sehmi R; Foley R; Alam R; Byrne PO; Denburg JA
Journal
The Open Respiratory Medicine Journal, Vol. 2, No. 1, pp. 60–66
Publisher
Bentham Science Publishers
Publication Date
2008
DOI
10.2174/1874306400802010060
ISSN
1874-3064