Primary thrombocythaemia in childhood: Symptomatic episodes and their relationship thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: A case report

In a child with primary thrombocythaemia, observations have been made over a period of five years, during which, transient apparently thrombotic events occurred in the central nervous system on several occasions. Spontaneous platelet aggregation was noted and deaggregation took place even after exposure to ADP in vitro. Associated findings included pronounced elevation in plasma levels of 6-keto-PGF1 alpha and 6-keto-PGE1, the latter described …