Journal article
The Mechanisms of Propofol-Induced Vascular Relaxation and Modulation by Perivascular Adipose Tissue and Endothelium
Abstract
BACKGROUND: Propofol causes hypotension due to relaxation of vascular smooth muscle cells through its direct or indirect vasodilator effects. Perivascular adipose tissue (PVAT) and endothelium attenuate vascular contraction, and the function of PVAT is altered in hypertension and diabetes. Whether PVAT affects the action of anesthetics on vascular function is unknown. We studied the mechanisms of propofol-induced relaxation in relation to the …
Authors
Kassam SI; Lu C; Buckley N; Lee RMKW
Journal
Anesthesia & Analgesia, Vol. 112, No. 6, pp. 1339–1345
Publisher
Wolters Kluwer
Publication Date
June 2011
DOI
10.1213/ane.0b013e318215e094
ISSN
0003-2999