Journal article
An enzymatic approach to lactate production in human skeletal muscle during exercise
Abstract
PURPOSE: This paper examines the production of lactate in human skeletal muscle over a range of power outputs (35-250% VO2max) from an enzymatic flux point of view. The conversion of pyruvate and NADH to lactate and NAD in the cytoplasm of muscle cells is catalyzed by the near-equilibrium enzyme lactate dehydrogenase (LDH). As flux through LDH is increased by its substrates, pyruvate and NADH, the factors governing the production of these …
Authors
SPRIET LL; HOWLETT RA; HEIGENHAUSER GJF
Journal
Medicine & Science in Sports & Exercise, Vol. 32, No. 4, pp. 756–763
Publisher
Wolters Kluwer
Publication Date
April 2000
DOI
10.1097/00005768-200004000-00007
ISSN
0195-9131